Thermo Fisher Scientific Phospho-IKK beta (Tyr188) Polyclonal Antibody
IKK beta 단백질의 Tyr188 인산화 상태를 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며 Protein A로 정제된 고품질 항체. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-IKK beta (Tyr188) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr188 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Phosphorylation of serine residues on I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other stresses.
It functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on key serine residues, leading to their polyubiquitination and proteasomal degradation.
This process releases NF-kappa-B, enabling nuclear translocation and activation of genes involved in immune response, growth control, and protection against apoptosis.
Mutations in the IKK beta gene can cause Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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