Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody
IP3 Receptor 2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 인간 시료에 반응합니다. 고순도 액상 형태로 제공되며, -20°C에서 보관합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PIEESNILSPVQD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2932857 |
Product Specific Information
- No cross-reactivity expected with other types of ITPR.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Inositol 1,4,5-trisphosphate (IP3) acts as a second messenger for many growth factors, hormones, and neurotransmitters. Upon binding to IP3 receptor (IP3R), IP3 triggers the release of intracellular calcium into the cytosol. Functional IP3R forms homo- or heterotetramers of ~240 kDa glycoprotein subunits. IP3R is structurally and functionally related to the ryanodine receptor, another intracellular calcium-release channel.
The similarity between IP3R and ryanodine receptor extends to their association with the immunophilin protein FKBP12. Phosphorylation of IP3R by PKC increases IP3-mediated calcium release, while dephosphorylation by calcineurin reduces calcium release, resulting in calcium oscillations. Mammalian IP3R subunits are encoded by three distinct genes with differential expression patterns:
- IP3R-I: heart, liver, kidney, ovary, and Purkinje neurons
- IP3R-II: predominantly in brain
- IP3R-III: pancreatic islets, kidney, and gastrointestinal tract
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.