Thermo Fisher Scientific ZRANB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ZNF265.

Target Information

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass transcriptional activation or repression.
ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1, or ZIS2, is a 330 amino acid protein belonging to the ZRANB2 family.
Localized to the nucleus, ZNF265 functions as a splicing factor responsible for alternative splicing of Tra-2 beta transcripts and may interfere with constitutive 5′-splice selection.
ZNF265 contains two RanBP2-type zinc fingers that mediate RNA-binding activity. Two isoforms, ZIS-1 and ZIS-2, arise from alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.