Thermo Fisher Scientific IL-33 Polyclonal Antibody
IL-33 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상형 제품. 인간 시료 반응성, 비결합형 상태로 제공되며, 2-8°C 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- PA520397
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | 20 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the amino terminus of human IL-33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153521 |
Product Specific Information
Despite its predicted molecular weight, IL-33 often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is human lymph node tissue lysate.
PA5-20397 can be used with blocking peptide PEP-0514.
Target Information
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain.
IL-33 functions both as a proinflammatory cytokine and as an intracellular nuclear factor with transcriptional regulatory properties.
It binds to and signals through IL1RL1/ST2, recruiting MYD88, IRAK1, IRAK4, and TRAF6.
IL-33 activates NF-kappaB and MAP kinases, driving production of TH2-associated cytokines (IL-4, IL-5, IL-13).
It is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules of tonsils, Peyer’s patches, and mesenteric lymph nodes.
Prolonged IL-33 treatment in mice leads to eosinophilia, splenomegaly, and severe mucosal organ pathology.
IL-33 also co-localizes with heterochromatin and has transcriptional repressor activity, functioning as both a cytokine and nuclear factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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