Thermo Fisher Scientific IL-33 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Despite its predicted molecular weight, IL-33 often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is human lymph node tissue lysate.
PA5-20397 can be used with blocking peptide PEP-0514.

Target Information

IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain.
IL-33 functions both as a proinflammatory cytokine and as an intracellular nuclear factor with transcriptional regulatory properties.
It binds to and signals through IL1RL1/ST2, recruiting MYD88, IRAK1, IRAK4, and TRAF6.
IL-33 activates NF-kappaB and MAP kinases, driving production of TH2-associated cytokines (IL-4, IL-5, IL-13).
It is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules of tonsils, Peyer’s patches, and mesenteric lymph nodes.
Prolonged IL-33 treatment in mice leads to eosinophilia, splenomegaly, and severe mucosal organ pathology.
IL-33 also co-localizes with heterochromatin and has transcriptional repressor activity, functioning as both a cytokine and nuclear factor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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