Thermo Fisher Scientific SERPINB7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SERPINB7. Recombinant protein control fragment (Product #RP-101064). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SERPINB7,uniProtId:O75635-1,ncbiNodeId:9606,antigenRange:203-334,antigenLength:380,antigenImageFileName:PA5-55011_SERPINB7_O75635-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55011_SERPINB7_O75635-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647151

Product Specific Information

Immunogen sequence: KAVAMMHQER KFNLSVIEDP SMKILELRYN GGINMYVLLP ENDLSEIENK LTFQNLMEWT NPRRMTSKYV EVFFPQFKIE KNYEMKQYLR ALGLKDIFDE SKADLSGIAS GGRLYISRMM HKSYIEVTEE GT

Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 72%.

Target Information

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.