Thermo Fisher Scientific USP13 Monoclonal Antibody (OTI4G11)
USP13 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. 인간, 개, 영장류 반응성. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunoprecipitation (IP) | 4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G11 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human USP13 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725636 |
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10, and is involved in processes including autophagy and endoplasmic reticulum-associated degradation (ERAD).
It forms part of a regulatory loop that controls autophagy and p53/TP53 levels by stabilizing complexes containing PIK3C3/VPS34.
USP13 deubiquitinates USP10, a regulator of p53 stability, and interacts with UFD1 to mediate SKP2 deubiquitination.
Also regulates ERAD through deubiquitination of UBL4A and stabilizes SIAH2 independently of deubiquitinase activity.
Preferentially cleaves Lys-63-linked polyubiquitin chains and may cleave ISG15 in vitro.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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