Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI26C4), TrueMAB
Human PDCD1 단백질을 인식하는 mouse monoclonal antibody로, WB, ICC/IF, Flow Cytometry에 사용 가능. 고순도 affinity chromatography 정제, 1 mg/mL 농도, 안정적인 PBS/BSA/glycerol buffer 구성. 연구용 면역반응 조절 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:900 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI26C4 |
| Immunogen | Full length human recombinant PDCD1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (PDCD1), which bind ligands PDL-1 and PDL-2 to downregulate immune activation. PD-1 signaling inhibits T-cell activation in the absence of danger signals like LPS. PD1-deficient mice show hyperactivated immune systems and autoimmune diseases. Although PD-1 has a predicted molecular weight, it often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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