Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI27E8), TrueMAB
인간 PDCD1 단백질을 인식하는 마우스 단클론 항체입니다. Flow Cytometry에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI27E8 |
| Immunogen | Full-length human recombinant PDCD1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (PDCD1) that mediate inhibitory signals from APCs.
PD-1 binds two ligands, PDL-1 and PDL-2. Upon binding, PD-1 transmits inhibitory signals that suppress immune activation in the absence of danger signals such as LPS or other pathogen-associated molecules. PD-1 knockout mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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