Thermo Fisher Scientific CBF beta Recombinant Rabbit Monoclonal Antibody (JG39-35)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive Control: Rat kidney tissue, human kidney tissue, SiHa cells.

Target Information

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. It regulates genes involved in hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA-binding regulatory subunit that enhances DNA binding by the alpha subunit. The complex interacts with the core sites of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.
Alternative splicing generates two mRNA variants with distinct carboxyl termini. A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can produce a chimeric transcript combining the N terminus of CBF beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia subtype M4Eo. Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.