Thermo Fisher Scientific ARID1A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
PGLGNVAMGP RQHYPYGGPY DRVRTEPGIG PEGNMSTGAP QPNLMPSNPD SGMYSPSRYP PQQQQQQQQR HDSYGNQFST QGTPSGSPFP SQQTTMYQQQ QQNYK

Highest antigen sequence identity:

• Mouse: 95%
• Rat: 88%

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin.
It possesses at least two conserved domains important for function:

1. A DNA-binding domain that specifically binds an AT-rich DNA sequence recognized by the SNF/SWI complex at the beta-globin locus.
2. A C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation.

This protein may confer specificity to the SNF/SWI complex and recruit it to target genes through protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.