Thermo Fisher Scientific ERK5 Polyclonal Antibody
ERK5 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin)에 적합. 인간 MAPK7 C-말단 펩타이드로 면역화. 다양한 종에서 교차 반응 예측. 세포 신호전달 및 발달 연구에 유용.
- 카탈로그번호
- PA514416
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 776–805 amino acids from the C-terminal region of human MAPK7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2140432 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, and rat based on sequence homology.
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK7 is activated by MAP2K5/MEK5 and mediates downstream signaling of multiple receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression by phosphorylating transcription factors. Gene deletion in mice leads to defective cardiovascular development and embryonic lethality. ERK5 plays a key role in endothelial function and vascular integrity. It is expressed in adult tissues such as heart, placenta, lung, kidney, and skeletal muscle, but not in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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