Thermo Fisher Scientific TMSB4X Polyclonal Antibody
TMSB4X 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 Affinity chromatography로 정제되었습니다. PBS/glycerol 버퍼에 저장되며 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TMSB4X (Accession P62328), corresponding to amino acid residues M1–K32 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815648 |
Product Specific Information
This antibody detects endogenous levels of total TMSB4X.
Target Information
Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family. It is found at high concentrations in the spleen, thymus, and peritoneal macrophages, where it plays a key role in cytoskeletal organization. In mammalian tissues, it modulates actin polymerization and depolymerization by forming a 1:1 complex with G-actin, inhibiting its polymerization into F-actin. This process, along with other cytoskeletal proteins, contributes to microfilament structure formation.
Thymosin-beta4 is widely distributed in the brain, lungs, liver, kidneys, testes, and heart, and is also synthesized by non-reticuloendothelial cells such as myoblasts and fibroblasts. It is expressed variably in several hematopoietic and malignant lymphoid cell lines. Beyond actin regulation, thymosin-beta4 influences hormonal secretion, macrophage migration, T-cell differentiation, and hematopoietic stem cell cycle progression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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