Thermo Fisher Scientific GGCX Polyclonal Antibody
Rabbit polyclonal antibody against human GGCX, validated for Western blot. High purity (>95%) via antigen affinity chromatography. Supplied as liquid at 1 mg/mL in PBS with 50% glycerol. Suitable for research on vitamin K-dependent protein carboxylation.
- 카탈로그번호
- PA576881
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human GGCX (1–758 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720608 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by epitope-specific immunogen affinity chromatography, achieving purity >95% as confirmed by SDS-PAGE.
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates the vitamin K-dependent carboxylation of glutamate residues on target proteins, generating calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and is essential for the activation of all vitamin K-dependent proteins, including those involved in blood coagulation and bone matrix formation.
Mutations in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, leading to abnormalities in skin, blood, or bone function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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