Thermo Fisher Scientific GGCX Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by epitope-specific immunogen affinity chromatography, achieving purity >95% as confirmed by SDS-PAGE.

Target Information

GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates the vitamin K-dependent carboxylation of glutamate residues on target proteins, generating calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and is essential for the activation of all vitamin K-dependent proteins, including those involved in blood coagulation and bone matrix formation.
Mutations in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, leading to abnormalities in skin, blood, or bone function.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.