Thermo Fisher Scientific UCMA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2.5-5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 16 amino acid peptide near the carboxy terminus of human UCMA. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UCMA,uniProtId:Q8WVF2-1,ncbiNodeId:9606,antigenRange:138,antigenLength:138,antigenImageFileName:PA5-20768_UCMA_Q8WVF2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-20768_UCMA_Q8WVF2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152272

Product Specific Information

A suggested positive control is SW1353 cell lysate.

PA5-20768 can be used with blocking peptide PEP-0882.

Target Information

UCMA is a gene that encodes for a protein that is specific to chondrocytes and highly charged. This protein is expressed abundantly in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the protein has been associated with osteoarthritis in humans. Alternative splicing of the gene results in multiple transcript variants that encode different isoforms. UCMA is also associated with diseases such as Osteoarthritis and Poland Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.