Thermo Fisher Scientific IRS1 Monoclonal Antibody (OTI9E11), TrueMAB
인슐린 수용체 기질 단백질 IRS1을 표적하는 Mouse IgG2a 단클론 항체로, Western blot 및 IHC(Paraffin) 적용 가능. 인간 반응성, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–280 of human IRS1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation by insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4).
IRS-1 is phosphorylated on serine, threonine, and tyrosine residues in various tissues. Casein kinase II mediates part of the insulin-stimulated serine/threonine phosphorylation of IRS-1 in vivo.
Thr502 and Ser99 are identified phosphorylation sites catalyzed by casein kinase II. This phosphorylation may be a component of the intracellular insulin signaling cascade.
IRS-1 also contains three putative 14-3-3 binding sites (Ser270, Ser374, Ser641), with the motif around Ser270 located in the phosphotyrosine-binding domain responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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