Thermo Fisher Scientific ITGB5 Polyclonal Antibody
Human ITGB5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 비보존제 액상 형태. 세포막 인테그린 연구용으로 적합.
- 카탈로그번호
- PA517260
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:25 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Lys789 of human integrin β5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 60 µg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980802 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are heterodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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