Thermo Fisher Scientific TRPC5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

-

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

-

Immunocytochemistry (ICC/IF)

1:120

-

Immunoprecipitation (IP)

Assay-Dependent

-

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide (C)HKWGDGQEEQVTTRL, corresponding to amino acid residues 959-973 of human TRPC5 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRPC5,uniProtId:Q9UL62-1,ncbiNodeId:9606,antigenRange:959-973,antigenLength:973,antigenImageFileName:PA5-77310_TRPC5_Q9UL62-1_Rabbit.svg,antigenImageFileNamePDP:PA5-77310_TRPC5_Q9UL62-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2736733

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.

Target Information

TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.