Thermo Fisher Scientific TMC6 Polyclonal Antibody
Rabbit polyclonal antibody recognizing TMC6 protein. Validated for WB and IHC applications. Lyophilized form, reconstitutable with distilled water. Suitable for human samples. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TMC6 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2271884 |
Product Specific Information
- Reconstitute with 100 µL of distilled water.
- Centrifuge to remove any insoluble material.
Target Information
TMC6 interacts with and forms a complex with the zinc transporter 1 (SLC30A1), and localizes to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels.
This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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