Thermo Fisher Scientific Thrombopoietin Recombinant Rabbit Monoclonal Antibody (444)
Recombinant rabbit monoclonal antibody for Mouse Thrombopoietin detection. High specificity and sensitivity with consistent lot performance. Preservative-free formulation suitable for ELISA applications. Stable for long-term storage at -20°C.
- 카탈로그번호
- MA529831
- 판매단위
- pk
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Applications
ELISA (ELISA)
- Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 444 |
| Immunogen | Recombinant Mouse Thrombopoietin/THPO protein (Met1–Thr356) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785651 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened for optimal performance.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
This antibody is specific for Mouse Thrombopoietin (THPO).
Target Information
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is a key regulator in platelet generation. It acts on hematopoietic cells committed to the megakaryocyte lineage. Upon binding to its receptor MPL (CD110), it activates signaling pathways including JAK/STAT, MAPK, and PI3K/AKT, leading to megakaryocyte proliferation and differentiation, ultimately resulting in platelet production (thrombopoiesis).
Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of approximately 38 kDa.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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