Thermo Fisher Scientific KDM5B Monoclonal Antibody (CL1129)
인간 KDM5B 단백질을 인식하는 Thermo Fisher Scientific의 CL1129 단일클론 항체입니다. WB, IHC, ICC 등 다양한 응용에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 4°C 또는 -20°C 보관, 연구용으로만 사용됩니다.
- 카탈로그번호
- MA524626
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- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL1129 |
| Immunogen | Recombinant protein corresponding to Human KDM5B (aa 1401–1481) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637241 |
Product Specific Information
- Immunogen sequence:
DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS E - Highest antigen sequence identity:
Mouse – 86%, Rat – 91% - Epitope binding:
Binds to an epitope located within the peptide sequence DGINSLERKLKRRLE as determined by overlapping synthetic peptides.
Target Information
KDM5B is a histone demethylase that specifically demethylates Lys-4 of histone H3, playing a central role in the histone code. It does not demethylate histone H3 Lys-9 or Lys-27. KDM5B acts as a transcriptional corepressor for FOXG1B and PAX9, promoting proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. Conversely, it may act as a tumor suppressor in melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-24626_KDM5B_Q9UGL1-1_House_mouse.svg, MA5-24626_KDM5B_Q9UGL1-1_House_mouse_PDP.jpeg)
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