Thermo Fisher Scientific HSF2 Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total HSF2 protein.

Target Information

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated as heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcriptional level. Heat shock transcription factors (HSF1 and HSF2) are key regulators in this process.

HSF1 and HSF2 are upregulated by estrogen at both mRNA and protein levels. HSF1 typically exists as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA-binding activity, and translocates to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.