Thermo Fisher Scientific HINT1 Polyclonal Antibody
HINT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며, KLH 접합 합성 펩타이드(aa 41-126)를 면역원으로 사용했습니다. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HINT1, amino acids 41–126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. It catalyzes the hydrolysis of adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, though this enzymatic function does not appear to play a role in tumor suppression. HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and c-Jun phosphorylation, contributing to tumor suppressor activity. Other studies suggest HINT1 may be a candidate gene for schizophrenia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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