Thermo Fisher Scientific PLXDC1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PLXDC1 (AAH36059.1, 1 a.a. approximately 500 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TEM7,uniProtId:Q8IUK5-1,ncbiNodeId:9606,antigenRange:1-500,antigenLength:500,antigenImageFileName:H00057125-D01P_TEM7_Q8IUK5-1_Rabbit.svg,antigenImageFileNamePDP:H00057125-D01P_TEM7_Q8IUK5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ ITMATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC

Target Information

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.