Thermo Fisher Scientific UCP3 Monoclonal Antibody (6B8C6)
UCP3 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, ICC/IF, ELISA에 적합. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도의 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B8C6 |
| Immunogen | Purified recombinant fragment of human UCP3 (AA: 1–113 and 217–312) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787570 |
Product Specific Information
MA5-31947 has been tested in indirect ELISA.
Target Information
The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, uncoupling oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane.
This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism.
UCP2 is a structurally related protein that also uncouples mitochondrial respiration and is more widely expressed in human and mouse tissues, including white adipose tissue and muscle. It is thought to play a role in body weight regulation.
UCP3, a highly muscle-specific protein, is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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