Thermo Fisher Scientific IL-1 Beta Polyclonal Antibody
다양한 종에서 반응하는 IL-1 Beta 폴리클로날 항체로, WB, IHC, ICC, ELISA 등에 사용 가능. Rabbit IgG 기반으로 Protein A 정제. 염증 반응 관련 연구에 적합하며 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-1 Beta (amino acids 161–269) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as an inactive 31 kDa pro-form that accumulates in the cytosol and is cleaved by activated caspase-1 into an active 17 kDa form following inflammasome activation. IL-1β is secreted through a non-classical pathway and signals via IL-1RI and IL-1RII receptors, shared with IL-1α. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which competitively inhibits receptor binding. IL-1β plays a critical role in innate immune responses and inflammation, and elevated levels are linked to chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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