Thermo Fisher Scientific RNF47 Polyclonal Antibody
RNF47 단백항체는 인간, 마우스, 랫트에 반응하며 다양한 응용(서던 블롯, IHC, ICC, ELISA)에 적합합니다. Rabbit IgG 폴리클로날 항체로서 BFAR 단백질을 표적하며, 고순도 Protein A 정제 및 안정적인 액상 포맷으로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Bifunctional apoptosis inhibitor (BFAR), amino acids 301–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The bifunctional apoptosis inhibitor (BFAR) is a scaffold protein that integrates signaling components of the cell’s apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors (extrinsic pathway) as well as mitochondria-dependent apoptosis (intrinsic pathway). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain contributes to its anti-apoptotic properties. Additionally, BFAR contains a DED-like domain that suppresses apoptosis mediated at the receptor level and may play a role in neuronal survival regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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