Thermo Fisher Scientific CD28 Polyclonal Antibody
인간 CD28 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공됩니다. T세포 활성화 연구에 적합합니다.
- 카탈로그번호
- PA584832
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD28. Recombinant protein control fragment (Product # RP-107728) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791981 |
Product Specific Information
Immunogen sequence:
RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR S
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes.
CD28 acts as a critical T cell costimulatory receptor providing the second activation signal by binding CD80 and CD86 on antigen-presenting cells. It prevents T cells from entering an anergic or apoptotic state.
In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28. In the thymus, expression is highest on immature CD3-, CD8+, and CD4+8+ cells, as well as CD4-8- cells expressing α/β and γ/δ TCR. Expression on mature thymocytes is two- to fourfold lower than on immature cells.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sézary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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