Thermo Fisher Scientific Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker) Monoclonal Antibody (SERPINA3/4187)
인간 SERPINA3를 인식하는 단클론 항체로, IHC 및 펩타이드 배열 분석에 적합. 알츠하이머병 관련 연구 및 조직학적 히스티오사이트 표지에 활용 가능. 단백질 A/G 정제, 1 mg/mL 농도, PBS 버퍼에 보존.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SERPINA3/4187 |
| Immunogen | Recombinant human Antichymotrypsin (AACT) protein fragment (around aa 49–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SERPINA3 encodes Alpha-1-Antichymotrypsin (Alpha 1-ACT), an early-stage acute-phase plasma protein and serine protease inhibitor.
It preferentially inactivates chymotrypsin, cathepsin G, and chymase.
Alpha-1-ACT is associated with amyloid plaques in Alzheimer’s disease and aged brain tissue.
Regulation of serine proteases and their inhibitors plays a key role in neuromuscular differentiation.
Prostate-specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed with Alpha-1-ACT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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