Thermo Fisher Scientific HdmX/MDM4 Polyclonal Antibody
MDMX/MDM4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP 실험에 적합. 비결합형 액상 형태이며 4°C에서 보관. p53 안정성 조절 연구 등 암 관련 단백질 연구에 활용 가능.
- 카탈로그번호
- A300287AM
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 125–175 of human ortholog of mouse double minute 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene encoding MDMX (also designated MDM4) is often amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, increasing p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes its levels, thereby increasing the half-life of p73 through MDM2 binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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