Thermo Fisher Scientific AFAP1L2 Monoclonal Antibody (2H6D1)
AFAP1L2 단백질을 인식하는 Mouse monoclonal antibody(클론 2H6D1). Western blot, Flow cytometry, ELISA에 사용 가능. Human 시료 반응성. Protein G로 정제된 액상형 제품으로, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H6D1 |
| Immunogen | Purified recombinant fragment of human AFAP1L2 (AA: 674–818) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787238 |
Product Specific Information
MA5-31614 has been tested in indirect ELISA.
Target Information
AFAP1L2 (also known as XB130) is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and multiple potential phosphorylation sites.
It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduces Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3β, and alters cell cycles in human lung epithelial cells, suggesting a role as an adaptor in Src signal transduction and cellular regulation.
AFAP1L2 is highly expressed in thyroid tissue and acts as a substrate for RET/PTC kinase, which plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 reduces Akt activity, inhibiting cell-cycle progression and cancer cell survival, indicating its potential as a therapeutic target in thyroid cancer.
At least four isoforms of AFAP1L2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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