Thermo Fisher Scientific MMRN1 Polyclonal Antibody
Human MMRN1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. Multimerin-1 단백질 연구용으로 사용.
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- PA557392
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MMRN1. Recombinant protein control fragment (Product #RP-96663). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644016 |
Product Specific Information
Immunogen sequence:
RHNLLRNEVQ GRDDALERRI NEYALEMEDG LNKTMTIINN AIDFIQDNYA LKETLSTIKD NSEIHHKCTS DMETILTFIP QFHRLND
Highest antigen sequence identity to the following orthologs:
- Mouse: 66%
- Rat: 63%
Target Information
Protein: Multimerin-1 (MMRN1)
Also known as: EMILIN-4, ECM (endothelial cell multimerin)
Multimerin-1 is a 1,228 amino acid secreted protein containing one C1q domain, one EMI domain, and one EGF-like domain. It is synthesized in megakaryocytes and endothelial cells and found in liver, lung, and placenta. Multimerin-1 forms multimeric structures via disulfide bonds and functions as a carrier protein for platelet factor V, contributing to its stabilization and storage in platelets. It also acts as a ligand for select integrins, participating in extracellular matrix adhesion. Defects in the MMRN1 gene are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms exist due to alternative splicing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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