Thermo Fisher Scientific NDST1 Monoclonal Antibody (1G10)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1G10

Immunogen

NDST1 (NP_001534, 38 a.a. approximately 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NDST1,uniProtId:P52848-1,ncbiNodeId:9606,antigenRange:38-136,antigenLength:882,antigenImageFileName:H00003340-M01A_NDST1_P52848-1_House_mouse.svg,antigenImageFileNamePDP:H00003340-M01A_NDST1_P52848-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: LYGWKRGLEP SADAPEPDCG DPPPVAPSRL LPLKPVQAAT PSRTDPLVLV FVESLYSQLG QEVVAILESS RFKYRTEIAP GKGDMPTLTD KGRGRFALI

Target Information

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.