Thermo Fisher Scientific HYAL1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAGTLQLGRA LRPRGLWGFY GFPDCYNYDF LSPNYTGQCP SGIRAQNDQL GWLWGQSRAL YPSIYMPAVL EGTGKSQMYV QHRVAEAFRV AVAAGDPNLP VLPYVQIFYD TTNHFLPLDE LEHSLGESAA QGAAGVVLWV SWENTRTKES CQAIKEYMDT TLGPFILNVT SGALLCSQAL CSGHGRCVRR TSHPKALLLL NPASFSIQLT PGGGPLSLRG ALSLEDQAQM AVEFKCRCYP GWQAPWCERK SMW

Target Information

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, a major glycosaminoglycan of the extracellular matrix. Hyaluronan is involved in cell proliferation, migration, and differentiation. This enzyme is active at acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX (hyaluronidase deficiency). The gene is located in chromosome 3p21.3, a region linked to tumor suppression. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.