Thermo Fisher Scientific BPI Polyclonal Antibody
Thermo Fisher Scientific의 BPI Polyclonal Antibody는 인간 및 생쥐 시료에 반응하는 토끼 유래 다클론 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. BPI 단백질 연구 및 항균 메커니즘 분석에 유용합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human BPI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720443 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
The antimicrobial protein BPI (Bactericidal Permeability Increasing protein) is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also on the surface of neutrophils, small intestinal, and oral epithelial cells. BPI exhibits high affinity for the lipid A region of lipopolysaccharides (LPS) in gram-negative bacterial membranes, leading to multiple anti-infective activities such as:
- Cytotoxicity via membrane disruption
- Neutralization of gram-negative bacterial LPS
- Opsonization to enhance phagocytosis by neutrophils
BPI expression in airway epithelial cells suggests a role in LPS-triggered airway disease and inflammation. Recombinant fragment rBPI21 (21 kDa) has been shown to provide protection against invasive pneumococcal disease by binding pneumolysin, a gram-positive bacterial toxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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