Thermo Fisher Scientific TCP-1 zeta Polyclonal Antibody
TCP-1 zeta 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TCP-1 zeta. Recombinant protein control fragment (Product #RP-104349). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648330 |
Product Specific Information
Immunogen sequence:
GVWDNYCVKK QLLHSCTVIA TNILLVDEIM RAGMSSLK
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 100%
Target Information
The protein TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT complex consists of eight different subunit species—TCP-1 alpha, beta, gamma, delta, epsilon, zeta, eta, and theta—each encoded by a distinct gene. Two zeta subunits have been described: TCP-1 zeta (also designated TCP-1 zeta1) and TCP-1 zeta2. TCP-1 subunits are proposed to have independent functions in folding in vivo substrates, such as actins and tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Homologous sequences have been isolated in several species, and yeast TCP-1 encodes a molecular chaperone for actin and tubulin. TCP-1 in mammalian cells and yeast plays an important role in folding cytosolic proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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