Thermo Fisher Scientific POLR3E Polyclonal Antibody

Thermo Fisher Scientific POLR3E Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.04–0.4 µg/mL
• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
VRPASMTYDD IPHLSAKIKP KQQKVELEMA IDTLNPNYCR SKGEQIALNV DGACADETST YSSKLMDKQT FCSSQTTSNT SRYAAALYRQ GELHLTPLHG ILQLRPSFSY LDK

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters.
Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.
Acts as nuclear and cytosolic DNA sensor involved in innate immune response.
Can sense non-self dsDNA that serves as template for transcription into dsRNA.
The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-κB through the RIG-I pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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