Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive control: Hela cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, Hela
• Predicted band size: 35 kDa
• Subcellular Location: Cell membrane, Cytoplasm

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses. T cell activation induces expression of this gene, increasing osteoclastogenesis and bone loss. It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation. Gene disruption in mice leads to severe osteopetrosis, lack of osteoclasts, and defects in T and B lymphocyte differentiation, as well as impaired mammary gland development during pregnancy. Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.