Thermo Fisher Scientific Human RIP1 Synthetic Peptide
인간 RIPK1의 아미노 말단 15개 아미노산 서열 기반 합성 펩타이드. 항체 PA5-20811의 블로킹 펩타이드로 사용 가능. 세포사멸 및 염증 신호전달 연구용. PBS 완충액에 BSA 포함, -20°C 보관.
- 카탈로그번호
- PEP0925
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human RIPK1.
PEP-0925 can be used as a blocking peptide with polyclonal antibody PA5-20811.
Target Information
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptor ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, thereby activating the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-linked chains enhances communication with downstream signal transducers in MAPK and NF-kappa-B pathways, leading to activation of inflammatory gene expression. Polyubiquitinated protein binds to IKBKG/NEMO, a critical event for NF-kappa-B activation. Interaction with other RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association forms a necrosis-inducing complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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