Thermo Fisher Scientific Human RIP1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human RIPK1.
PEP-0925 can be used as a blocking peptide with polyclonal antibody PA5-20811.

Target Information

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptor ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, thereby activating the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-linked chains enhances communication with downstream signal transducers in MAPK and NF-kappa-B pathways, leading to activation of inflammatory gene expression. Polyubiquitinated protein binds to IKBKG/NEMO, a critical event for NF-kappa-B activation. Interaction with other RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association forms a necrosis-inducing complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.