Thermo Fisher Scientific TIAF1 Polyclonal Antibody
Rabbit polyclonal antibody specific for human TIAF1 단백질 검출용. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약. 4°C 단기 보관, 장기 보관은 -20°C 권장. 연구용 전용 제품.
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TIAF1. Recombinant protein control fragment (Product # RP-100356) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648457 |
Product Specific Information
Immunogen sequence:
MSSPSSPFRE QSFLCAAGDA GEESRVQVLK NEVRRGSPVL LGWVEQAYAD KCV- Highest antigen sequence identity to the following orthologs:
- Mouse: 30%
- Rat: 28%
Target Information
TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that inhibits the cytotoxic effects of TNF-alpha, TRADD, and FADD.
It localizes to the nucleus and is significantly upregulated in activated helper T lymphocytes (TH2) during chronic kidney and liver allograft rejection.
Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation.
TIAF1 is essential in the p53- and WOX1-mediated cell death and plays a role in aggregation-dependent control of tumor progression, metastasis, and regulation of cell death.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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