ELK Biotechnology Oct-3/4 rabbit pAb
Oct-3/4 rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, 배아 발달 및 줄기세포 다능성 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 50kDa 밴드를 검출합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Oct-3/4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | POU5F1; OCT3; OCT4; OTF3; POU domain; class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human OCT3 (AA range: 191-240) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 5460 |
| Human Swiss-Prot No. | Q01860 |
| Cellular Localization | Cytoplasm, Nucleus. Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing’s sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (Provided by RefSeq, Oct 2013)
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