ELK Biotechnology NY-CO-9 rabbit pAb
HDAC5 유래 항원에 특이적인 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 핵과 세포질에 존재하며, 근육세포 분화 시 세포질로 이동. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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ELK Biotechnology NY-CO-9 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | NY-CO-9 rabbit pAb |
| Alternative Names | HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC5 (AA range: 1073–1122) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 121 kDa |
| GeneID (Human) | 10014 |
| Human Swiss-Prot No. | Q9UQL6 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Nucleus and cytoplasm. Shuttles between the nucleus and cytoplasm. In muscle cells, it relocates to the cytoplasm during myocyte differentiation. The export to cytoplasm depends on interaction with a 14-3-3 chaperone protein and phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1, and SIK1.
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
The protein encoded by this gene belongs to the class II histone deacetylase family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates with HDAC3 and may form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, leading to repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).
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