ELK Biotechnology N/H/K-Ras rabbit pAb
N/H/K-Ras 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 및 골지체 위치 단백질 검출에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
N/H/K-Ras rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NRAS; HRAS1; GTPase NRas; Transforming protein N-Ras; HRAS; HRAS1; GTPase HRas; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras; KRAS; KRAS2; RASK2; GTPase KRas; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1:100–300 ELISA: 1/20000 IF: 1:100–300 Not yet tested in other applications |
| Immunogen | The antiserum was produced against a synthesized peptide derived from human RASH/RASK (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 21 kD |
| GeneID (Human) | 3265 / 3845 / 4893 |
| Human Swiss-Prot No. | P01111 / P01112 / P01116 |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side; Golgi apparatus membrane; Lipid-anchor. Shuttles between plasma membrane and Golgi apparatus. |
| Species Reactivity | Human; Mouse; Rat |
Background
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.
The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein.
Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
(Provided by RefSeq, Jun 2011)
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