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ELK Biotechnology MRCKα rabbit pAb
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MRCKα 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 세포질 및 세포막 돌기 부위에 분포하며, 세포골격 재구성 연구에 유용합니다. 인체, 마우스, 랫트 시료에 반응합니다.
- 카탈로그번호
- ES2817-xxxxx (2개 옵션)
- 판매단위
- pk
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ELK Biotechnology ES2817-100UL MRCKα rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES2817-50UL MRCKα rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology MRCKα rabbit pAb
MRCKα rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MRCKα rabbit pAb |
| Alternative Names | CDC42BPA; KIAA0451; Serine/threonine-protein kinase MRCK alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from the internal region of human MRCKα (AA range: 580–660) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 200 kDa |
| Gene ID (Human) | 8476 |
| Human Swiss-Prot No. | Q5VT25 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cell projection, lamellipodium. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. |
Background
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains, with its kinase domain highly similar to that of the myotonic dystrophy protein kinase (DMPK). It also contains a Rac interactive binding (CRIB) domain and binds CDC42. MRCKα may act as a downstream effector of CDC42, mediating CDC42-induced peripheral actin formation and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, with full-length sequences reported for two of them (RefSeq, Jul 2008).
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