ELK Biotechnology MLKL rabbit pAb

제품명

MLKL rabbit pAb

제품 개요

MLKL(Mixed lineage kinase domain-like protein)은 세포괴사(necroptosis) 과정에 중요한 역할을 하는 단백질로, TNF 유도 세포사멸 경로에서 RIP3와 상호작용합니다. 본 항체는 MLKL 단백질을 인식하는 rabbit 폴리클로날 항체로, WB 및 IHC에 적합합니다.

제품 정보

Background

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain but is thought to be inactive because it lacks several residues required for activity. MLKL plays a critical role in TNF-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), a key signaling molecule in the necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of MLKL and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [RefSeq, Sep 2015]