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ELK Biotechnology mGluR-4 rabbit pAb
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ELK Biotechnology mGluR-4 rabbit pAb

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mGluR-4 rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 합성 펩타이드(AA 851-900)를 면역원으로 제작. 세포막에 위치한 mGluR4 단백질 검출에 적합. -20°C에서 1년 보관 가능.

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pk
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ELK Biotechnology ES2785-100UL mGluR-4 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES2785-50UL mGluR-4 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology mGluR-4 rabbit pAb

제품명

mGluR-4 rabbit pAb

제품 정보

항목 내용
Alternative Names GRM4; GPRC1D; MGLUR4; Metabotropic glutamate receptor 4; mGluR4
Applications WB; IHC; IF; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
Immunohistochemistry: 1/100 - 1/300
ELISA: 1/10000
Not yet tested in other applications
Immunogen The antiserum was produced against synthesized peptide derived from human mGluR4 (AA range: 851–900)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 100 kDa
Gene ID (Human) 2914
Human Swiss-Prot No. Q14833
Cellular Localization Cell membrane; Multi-pass membrane protein
Species Reactivity Human; Mouse; Rat

Background

Glutamate metabotropic receptor 4 (GRM4) is a G protein-coupled receptor expressed in the central nervous system. L-glutamate, the major excitatory neurotransmitter, activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is essential for normal brain function and is implicated in various neuropathologic conditions.
Metabotropic glutamate receptors are classified into three groups based on sequence homology, signaling mechanisms, and pharmacologic properties:

  • Group I: GRM1, GRM5 (activate phospholipase C)
  • Group II: GRM2, GRM3
  • Group III: GRM4, GRM6, GRM7, GRM8 (linked to inhibition of the cyclic AMP cascade, differing in agonist selectivity)
    Several transcript variants encoding different isoforms have been identified for this gene.

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