ELK Biotechnology LATS1/2 rabbit pAb
LATS1/2 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 주기 조절 및 종양 억제 관련 연구에 적합. 사람 및 생쥐 시료 반응성. 고순도 IgG, -20°C에서 1년 보관.
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제품명
LATS1/2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LATS1; WARTS; Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS2; KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 IF: 1/100–1/300 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human LATS1/2 (AA range: 1041–1090) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130–140 kDa |
| Gene ID (Human) | 9113 / 26524 |
| Human Swiss-Prot No | O95835 / Q9NRM7 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle, midbody. Localizes to centrosomes during interphase and migrates to the mitotic apparatus (spindle pole bodies, mitotic spindle, midbody) during mitosis. |
Background
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds its own N-terminal region, suggesting potential negative regulation via intramolecular binding. Biochemical and genetic data support a role as a tumor suppressor, consistent with knockout mouse studies showing development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogenic treatment.
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