ELK Biotechnology JNK3 rabbit pAb
JNK3 rabbit pAb는 MAPK10 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용됩니다. 신경계 세포에서 발현되는 JNK3 단백질 연구에 적합하며, 인간, 생쥐, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology JNK3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | JNK3 rabbit pAb |
| Alternative Names | MAPK10; JNK3; JNK3A; PRKM10; SAPK1B; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAPK10 (AA range: 361-410) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 5602 |
| Human Swiss-Prot No | P53779 |
| Cellular Localization | Cytoplasm; Membrane (Lipid-anchor); Nucleus; Mitochondrion. Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
[provided by RefSeq, Dec 2015]
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