ELK Biotechnology JIP-3 rabbit pAb
JIP-3 rabbit pAb는 인간 및 마우스 시료에서 사용 가능한 다클론 항체로, JNK 신호전달 경로 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 합성 펩타이드(AA 621-670)를 면역원으로 제작되었습니다. 세포질 및 골지체에 주로 발현됩니다.
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- ES2660-xxxxx (2개 옵션)
- 판매단위
- pk
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ELK Biotechnology JIP-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | JIP-3 rabbit pAb |
| Alternative Names | MAPK8IP3; JIP3; KIAA1066; C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human JIP3 (AA range: 621–670) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 147 kDa |
| GeneID (Human) | 23162 |
| Human Swiss-Prot No | Q9UPT6 |
| Cellular Localization | Cytoplasm; Golgi apparatus; Cytoplasmic vesicle; Cell projection (growth cone, axon, dendrite); Perinuclear region. Localized in soma and growth cones of differentiated neurites and in Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its role in neuronal axon elongation. |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene shares similarity with the Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in mouse suggest that this protein interacts with and regulates the activity of multiple kinases in the JNK signaling pathway, functioning as a scaffold protein in neuronal cells. The C. elegans homolog regulates synaptic vesicle transport by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants exist, though some full-length forms remain uncharacterized.
(Source: RefSeq, Jul 2008)
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