ELK Biotechnology JIP-1 rabbit pAb
JIP-1 rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. JIP1 유래 합성 펩타이드로 면역화되었으며, 세포질 및 핵에 위치합니다. β세포 기능 조절 및 당뇨병 관련 연구에 활용됩니다.
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ELK Biotechnology JIP-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | JIP-1 rabbit pAb |
| Alternative Names | MAPK8IP1; IB1; JIP1; PRKM8IP; C-Jun-amino-terminal kinase-interacting protein 1; JIP-1; JNK-interacting protein 1; Islet-brain 1; IB-1; JNK MAP kinase scaffold protein 1; Mitogen-activated protein kinase 8-interacting protein 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human JIP1 (AA range: 69–118) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 113, 78 kD |
| GeneID (Human) | 9479 |
| Human Swiss-Prot No | Q9UQF2 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; perinuclear region; nucleus; endoplasmic reticulum membrane; mitochondrion membrane; accumulates in cell surface projections; under stress, translocates to perinuclear region of neurons; in insulin-secreting cells, detected in both cytoplasm and nucleus (By similarity) |
Background
This gene encodes a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to regulate c-Jun amino-terminal kinase (Mapk8). This protein prevents MAPK8-mediated activation of transcription factors and decreases IL-1β and MEKK1-induced apoptosis in pancreatic beta cells. It also acts as a DNA-binding transactivator of the glucose transporter GLUT2. REST is reported to repress the expression of this gene in insulin-secreting beta cells. Mutations in this gene have been found in a type 2 diabetes family, suggesting it may be a susceptibility gene for type 2 diabetes. (RefSeq, May 2011)
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