ELK Biotechnology IRTKS rabbit pAb
IRTKS 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 BAIAP2L1 유래 펩타이드로 면역생성. 세포질 및 세포골격에 위치하며 actin 관련 신호전달 연구에 적합. -20°C 보관.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology IRTKS rabbit pAb
제품명
IRTKS rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BAIAP2L1 (AA range: 111-160) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 57 kD |
| GeneID (Human) | 55971 |
| Human Swiss-Prot No. | Q9UHR4 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytoskeleton. Recruited to actin pedestals formed upon bacterial infection at attachment sites. |
Background
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be divided into IRSp53-like and MIM-like groups based on the presence or absence of the SH3 (Src homology 3) domain.
The protein encoded by this gene contains a conserved IMD (F-actin bundling domain) at the N-terminus and a canonical SH3 domain near the C-terminus, classifying it as IRSp53-like.
It is a substrate for the insulin receptor tyrosine kinase and binds to the small GTPase Rac, participating in signal transduction pathways linking plasma membrane deformation and actin cytoskeleton remodeling.
Overexpression promotes actin assembly and membrane protrusions in mammalian cells and is essential for forming a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.